Powerful and rapid relief from mild to moderate pain, inflammation, and fever with COMBIFLAM TAB, a trusted combination medication containing Ibuprofen (400mg) and Paracetamol (325mg). This synergistic formulation is specifically made to provide comprehensive relief for a wide range of conditions, including headaches (including migraines), dental pain, menstrual cramps (dysmenorrhoea), muscle aches, joint pain, backaches, and post-operative pain. As a DPCO (Drugs (Prices Control) Order) regulated product, COMBIFLAM TAB ensures that this essential medicine remains accessible and affordable for patients in India, reflecting the government's commitment to public health.

Why COMBIFLAM TAB is Your Potent Choice for Effective Pain & Fever Management:

COMBIFLAM TAB combines two distinct yet complementary active ingredients to deliver a robust analgesic, antipyretic, and anti-inflammatory effect:

• Ibuprofen (Non-Steroidal Anti-Inflammatory Drug - NSAID - 400mg):

  • Mechanism: Ibuprofen works by inhibiting the production of prostaglandins. Prostaglandins are chemical messengers in the body that are responsible for causing pain, inflammation (redness and swelling), and fever.

  • Effect: By blocking these prostaglandins, Ibuprofen effectively reduces inflammation, swelling, and pain, making it particularly beneficial for conditions with an inflammatory component like arthritis, sprains, or post-operative pain. It also contributes to fever reduction.

• Paracetamol (Analgesic & Antipyretic - 325mg):

  • Mechanism: Paracetamol primarily acts in the brain to reduce pain and fever. While its exact mechanism is not fully understood, it is believed to work by inhibiting prostaglandin synthesis in the central nervous system and by acting on the heat-regulating center in the brain.

  • Effect: Paracetamol is a highly effective pain reliever and fever reducer, complementing Ibuprofen's anti-inflammatory action. It helps to lower elevated body temperature and provides significant pain relief.

• Synergistic Combination for Enhanced Relief:

  • Broader Pain Coverage: The combination provides a broader spectrum of pain relief, addressing both inflammatory and non-inflammatory pain pathways.

  • Faster Onset & Sustained Action: The dual action can lead to a quicker onset of pain relief and potentially more sustained effects compared to either drug alone for certain conditions.

  • Effective for Multiple Symptoms: Addresses pain, inflammation, and fever simultaneously, offering comprehensive symptomatic relief.

Key Benefits of COMBIFLAM TAB at a Glance:

• Powerful Dual-Action: Combines Ibuprofen and Paracetamol for enhanced pain relief.

• Reduces Inflammation: Ibuprofen specifically targets and alleviates swelling and redness.

• Effective Fever Reducer: Both components work to bring down elevated body temperature.

• Versatile Pain Management: Ideal for headaches, dental pain, menstrual cramps, muscle aches, and more.

• Rapid Symptomatic Relief: Designed for quick action against discomfort.

• DPCO Regulated: Ensures affordability and accessibility as an essential medicine.

Important Usage Instructions & Warnings for COMBIFLAM TAB (DPCO):

COMBIFLAM TAB is a prescription medication. Take it strictly as directed by your doctor. The dosage and duration of treatment will depend on your specific condition, severity of symptoms, and individual response. It is generally for short-term use only.

• Take with Food: It is highly recommended to take COMBIFLAM TAB with food or milk to minimize the risk of stomach upset, indigestion, and other gastrointestinal side effects.

• Swallow Whole: Swallow the tablet whole with a glass of water. Do not chew, crush, or break it.

• Dosage: The typical adult dosage is 1 tablet 3 times a day, with a minimum gap of 6 hours between doses. Do not exceed a total dose of 3 tablets (1200mg Ibuprofen / 975mg Paracetamol) in any 24-hour period.

• Duration of Use: For fever, do not use for more than 3 days. For pain, do not use for more than 4 days, unless explicitly recommended by a physician. If symptoms persist or worsen, consult your doctor.

• Contraindications & Serious Warnings:

  • Allergies: Do not use it if you are allergic to Ibuprofen, Paracetamol, Aspirin, or other NSAIDs (e.g., diclofenac, naproxen) or any other ingredients of the tablet.

  • Gastrointestinal Bleeding/Ulcers: Contraindicated in patients with active or a history of stomach ulcers, gastrointestinal bleeding, or perforation (especially related to previous NSAID therapy). NSAIDs can cause serious GI side effects, including bleeding and ulcers, which can be fatal.

  • Heart Failure & Cardiovascular Risk: Avoid in patients with severe heart failure (NYHA Class IV). NSAIDs, including Ibuprofen, may increase the risk of serious cardiovascular thrombotic events (like heart attack or stroke), especially with long-term use or high doses. This risk may increase with duration of use.

  • Kidney & Liver Problems: Use with caution in patients with mild to moderate kidney or liver impairment. Contraindicated in severe renal or hepatic failure. Long-term use can lead to kidney or liver damage.

  • Asthma/Respiratory Issues: Use with caution in patients with asthma, nasal polyps, or chronic obstructive respiratory disorders due to an increased risk of allergic reactions (e.g., asthma attacks).

  • Pregnancy & Lactation: Not recommended during pregnancy, especially in the third trimester due to potential harm to the fetus and complications during delivery. Not recommended during breastfeeding.

  • Children: Contraindicated in adolescents under 40 kg body weight and children below 12 years of age due to high active substance content.

• Masking Infection Symptoms: Ibuprofen can mask symptoms of infection (like fever and pain), which may delay appropriate treatment and worsen the infection's outcome.

• Drug Interactions: Inform your doctor about all other medications you are taking, including over-the-counter drugs, herbal supplements, and recreational drugs. Significant interactions include:

  • Other NSAIDs or COX-2 inhibitors (increased risk of side effects).

  • Blood thinners (anticoagulants like warfarin) - increased bleeding risk.

  • Corticosteroids (increased risk of GI ulcers/bleeding).

  • Certain antidepressants (SSRIs).

  • Blood pressure medications (ACE inhibitors, ARBs, diuretics) - reduced effectiveness and increased kidney risk.

  • Lithium, Methotrexate, Digoxin (increased levels of these drugs).

  • Cholestyramine, Metoclopramide, Domperidone (can affect absorption).

  • Other paracetamol-containing products (risk of liver overdose).

• Potential Side Effects: Common side effects include nausea, vomiting, abdominal pain, indigestion (dyspepsia), heartburn, diarrhea, constipation, headache, dizziness, skin rash, and itching. More serious, but less common, side effects include GI ulcers/bleeding, severe allergic reactions (difficulty breathing, swelling of face/throat), liver damage, kidney problems, heart palpitations, or severe skin reactions (Stevens-Johnson syndrome).

• If you experience any severe or persistent side effects, seek immediate medical attention.

• Avoid alcohol consumption while taking COMBIFLAM, as it can increase the risk of stomach upset and liver damage.

• Keep out of reach of children. Store in a cool, dry place, away from direct sunlight.