As a highly effective second-generation sulfonylurea, NB BIOGLICA 60 XR works continuously to stimulate your pancreas to release insulin, precisely managing elevated blood sugar levels in individuals with Type 2 Diabetes. Its once-daily XR formulation ensures stable glucose control throughout the entire day and night, significantly contributing to the prevention of long-term diabetes complications and supporting overall well-being.

Why NB BIOGLICA 60XR is a Preferred Choice for Type 2 Diabetes Management:

NB BIOGLICA 60 XR offers a sophisticated approach to consistent glucose control with added benefits:

• 24-Hour Sustained Glucose Control: The Extended-Release (XR) formulation of Gliclazide ensures a gradual and continuous release of the medication. This provides consistent blood sugar lowering throughout the entire 24-hour cycle with just a single daily dose, helping to avoid glucose fluctuations.

• Stimulates Insulin Secretion: Gliclazide effectively prompts the beta cells in your pancreas to produce and release more insulin, particularly in response to rising blood glucose levels after meals. Insulin is vital for transporting glucose from the bloodstream into your cells for energy.

• Maintains Pancreatic Function: Unlike some older sulfonylureas, Gliclazide is thought to have a more favorable effect on pancreatic beta-cell function over time, potentially helping to preserve insulin secretion capacity.

• Cardiovascular Benefits: Studies suggest Gliclazide may offer some cardiovascular benefits by reducing oxidative stress and improving endothelial function, contributing to better long-term heart health in diabetic patients.6

• Reduced Hypoglycemia Risk (Compared to some alternatives): While hypoglycemia (low blood sugar) is a potential side effect of sulfonylureas, Gliclazide is often associated with a lower risk compared to some other drugs in its class, especially when used appropriately.

• Convenient Once-Daily Dosing: The XR formulation simplifies your medication regimen, enhancing patient adherence and making daily diabetes management more manageable.

• Comprehensive Complication Prevention: By maintaining optimal blood sugar levels, NB BIOGLICA 60 XR plays a crucial role in preventing or delaying the onset and progression of severe diabetes-related complications affecting the eyes (retinopathy), kidneys (nephropathy), nerves (neuropathy), and the cardiovascular system.

Key Benefits of NB BIOGLICA 60 XR at a Glance:

• All-Day Blood Sugar Control: 24-hour sustained glucose lowering with once-daily dosing.

• Stimulates Insulin Naturally: Promotes pancreas to release more insulin.

• Pancreatic Preservation: May help maintain beta-cell function over time.

• Cardiovascular Advantage: Contributes to long-term heart health.

• Lower Hypoglycemia Risk: Favorable safety profile compared to some sulfonylureas.

• Prevents Complications: Guards against eye, kidney, nerve, and heart damage.

Important Usage Instructions for NB BIOGLICA 60 XR:

Always take NB BIOGLICA 60 XR exactly as prescribed by your doctor. Consistent adherence is vital for maintaining effective blood sugar control and preventing complications.

• Take one tablet (60mg XR) once daily, preferably with your breakfast, or as directed by your physician.

• Swallow the tablet whole with water; do not crush, chew, or break it, as this will disrupt the extended-release mechanism and could lead to rapid drug release and increased risk of side effects.

• It is crucial not to skip meals while on this medication, as this can significantly increase the risk of hypoglycemia (dangerously low blood sugar).

• Do not stop taking this medication suddenly without consulting your doctor, even if your blood sugar seems controlled.

• Regular monitoring of your blood sugar levels and HbA1c by your doctor is essential throughout treatment.

• Be aware of the signs and symptoms of hypoglycemia (dizziness, excessive sweating, rapid heartbeat, extreme hunger, confusion, tremors) and know how to treat it immediately (e.g., consume glucose tablets, fruit juice, or sugary candy).

Understanding How NB BIOGLICA 60 XR Works to Manage Diabetes:

Gliclazide, the active ingredient in NB BIOGLICA 60XR, belongs to the class of medications known as sulfonylureas. Its primary mechanism of action involves directly stimulating the pancreatic beta cells to increase insulin secretion.

• Binding to Receptors: Gliclazide binds to specific sulfonylurea receptors (SUR1) on the beta cell membrane.

• Potassium Channel Closure: This binding leads to the closure of ATP-sensitive potassium channels (KATP channels)

• Depolarization and Calcium Influx: The closure of these potassium channels causes depolarization of the beta cell membrane, which, in turn, opens voltage-dependent calcium channels.

• Insulin Release: The subsequent influx of calcium ions into the beta cell triggers the release of preformed insulin granules from the pancreas into the bloodstream.

The Extended-Release (XR) formulation ensures a slow and steady release of Gliclazide over 24 hours. This continuous presence of the drug helps to maintain stable blood glucose levels throughout the day and night with a single dose, reducing the peaks and troughs often seen with immediate-release formulations and potentially lowering the risk of hypoglycemia. Gliclazide specific binding to the pancreatic SUR1 receptor is also thought to contribute to its more favorable side effect profile and potential for beta-cell preservation.