This powerful dual-action tablet is manufactured for individuals with Type 2 Diabetes whose glucose levels are not adequately managed by a single medication. By synergistically addressing multiple pathways of glucose regulation, NB BIOGLICAMET 80/500 provides enhanced blood sugar lowering, contributing significantly to the prevention of long-term diabetes complications and promoting overall health.

Why NB BIOGLICAMET 80/500 is an Optimal Choice for Type 2 Diabetes Management:

NB BIOGLICAMET 80/500 offers a comprehensive and highly effective approach to glucose control:

• Dual-Mechanism for Enhanced Glucose Control:

  • Gliclazide (Sulfonylurea - 80mg): Directly stimulates the pancreatic beta cells to release more insulin, particularly after meals, helping to lower post-prandial blood sugar spikes. It also has potential benefits for maintaining beta-cell function and some antioxidant properties.

  • Metformin (Biguanide - 500mg): Works primarily by reducing glucose production by the liver (hepatic gluconeogenesis) and improving insulin sensitivity in muscle and fat cells, allowing the body to use insulin more effectively. It also decreases glucose absorption from the intestines.

  • This combination tackles high blood sugar from multiple angles, leading to more robust and sustained glucose reduction compared to monotherapy.

• Significant HbA1c Reduction: By combining these two complementary agents, NB BIOGLICAMET 80/500 achieves a more pronounced and durable reduction in HbA1c (Glycated Hemoglobin), a key indicator of long-term blood sugar control.

• Cardiovascular & Renal Benefits (from Metformin): Metformin, a cornerstone of Type 2 Diabetes treatment, has established benefits in reducing cardiovascular events and is often recommended as first-line therapy.

• Weight Neutrality or Modest Weight Loss: Unlike some other diabetes medications, Metformin often leads to weight neutrality or even modest weight loss, which is advantageous for many individuals with Type 2 Diabetes.

• Reduced Risk of Diabetes Complications: By consistently keeping blood sugar levels within a healthy range, NB BIOGLICAMET 80/500 plays a crucial role in preventing or delaying the onset and progression of severe diabetes-related complications affecting the eyes (retinopathy), kidneys (nephropathy), nerves (neuropathy), and the cardiovascular system.

• Convenient Combined Therapy: Offers the benefits of two essential medications in a single tablet, simplifying your treatment regimen and enhancing adherence.

Key Benefits of NB BIOGLICAMET 80/500 at a Glance:

• Powerful Dual-Action: Combines insulin stimulation with improved insulin sensitivity.

• Superior Glucose Control: Achieves significant reductions in blood sugar and HbA1c.

• Comprehensive Organ Protection: Helps reduce long-term diabetes complications.

• Weight Management: Often leads to weight neutrality or modest weight loss.

• Cardiovascular Advantages: Metformin component offers heart benefits.

• Simplified Dosing: Two key medications in one tablet for convenience.

Important Usage Instructions for NB BIOGLICAMET 80/500:

Always take NB BIOGLICAMET 80/500 exactly as prescribed by your doctor. Consistent adherence is vital for maintaining effective blood sugar control and preventing complications.

• Typically, take one tablet once or twice daily, preferably with or after meals, or as directed by your physician. Taking it with food helps reduce gastrointestinal side effects from Metformin.

• Swallow the tablet whole with water; do not crush, chew, or break it.

• It is crucial not to skip meals while on this medication, especially with Gliclazide, as this can increase the risk of hypoglycemia (low blood sugar).

• Do not stop taking this medication suddenly without consulting your doctor.

• Regular monitoring of your blood sugar levels, HbA1c, and kidney function by your doctor is essential throughout treatment.

• Be aware of the signs and symptoms of hypoglycemia (dizziness, excessive sweating, rapid heartbeat, extreme hunger, confusion, tremors) and know how to treat it immediately (e.g., consume glucose tablets, fruit juice, or sugary candy).

• Be aware of rare but serious side effects like lactic acidosis (muscle pain, unusual tiredness, trouble breathing, stomach pain); seek immediate medical attention if these occur.

Understanding How NB BIOGLICAMET 80/500 Works Synergistically:

NB BIOGLICAMET 80/500 integrates two distinct yet complementary mechanisms to achieve comprehensive blood sugar control:

• Gliclazide (Sulfonylurea): Its primary action is to increase insulin secretion from the pancreatic beta cells. It binds to sulfonylurea receptors on these cells, leading to the closure of ATP-sensitive potassium channels. This causes depolarization of the beta cell membrane, opening voltage-dependent calcium channels, and triggering the release of preformed insulin. This helps to lower post-meal blood glucose levels.

• Metformin (Biguanide): Works through several key pathways:

  • Decreases Hepatic Glucose Production: Reduces the amount of glucose produced by the liver.

  • Improves Insulin Sensitivity: Enhances the body's response to insulin, allowing cells in muscles and fat to absorb more glucose from the blood.

  • Reduces Intestinal Glucose Absorption: Decreases the amount of glucose absorbed from the food in the gut. Metformin does not directly stimulate insulin secretion, thus its risk of hypoglycemia as a monotherapy is minimal.

The combination of Gliclazide's insulin-stimulating effect and Metformin's actions on glucose production, absorption, and insulin sensitivity provides a powerful, multi-target approach that leads to more effective and sustained reductions in both fasting and post-meal blood sugar levels for individuals with Type 2 Diabetes.